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LARGACTIL is indicated in the following conditions:1.Schizophrenia and other psychoses (especially paranoid) mania and hypomania. 2.In anxiety psychomotor agitation excitement violent or dangerously impulsive behaviour. LARGACTIL is used as an adjunct in the short-term management of these conditions. 3.Intractable hiccup. 4.Nausea and vomiting of terminal illness (where other medicines have failed or are not available). 5.Induction of hypothermia is facilitated by LARGACTIL which prevents shivering and causes vasodilation. 6.Childhood schizophrenia and autism. Dosage and AdministrationOral administration should be used whenever possible. Dosages should be low to begin with and gradually increase under close supervision until the optimum dosage within the recommended range for the individual is reached. Individuals vary considerably and the optimum dose may be affected by the formulation used.The parenteral formulation may be used in emergencies. It may only be administered by deep intramuscular injection. LARGACTIL is too irritant to give subcutaneously. Repeated injections should be avoided if possible.Schizophrenia Psychoses Anxiety and AgitationOralAdultInitially 25 mg three times daily or 75 mg at bedtime increasing by daily amounts of 25 mg to an effective maintenance dose. This is usually in the range 75 to 300 mg daily but some patients may require up to 1 g daily.ChildrenUnder 1 Year: Do not use unless need is life saving.1-5 Years: 0.5 mg/kg bodyweight every 4 - 6 hours to a maximum recommended dose of 40 mg daily.6 -12 Years: A third to half the adult dose to a maximum recommended dose of 75 mg daily.ElderlyStart with a third to a half the usual adult dose with a more gradual increase in dosage.IntramuscularAdultFor acute relief of symptoms 25 - 50 mg every 6 - 8hours.ChildrenUnder 1 Year: Do not use unless need is life saving.1-5 Years: 0.5 mg/kg bodyweight every 6 - 8 hours. Dosage is not advised to exceed 40 mg daily.6-12 Years: 0.5 mg/kg bodyweight every 6 - 8 hours. Not to exceed 75 mg daily.ElderlyDoses in the lower range for adults should be sufficient to control symptoms i.e. 25 mg 8 hourly.Intractable HiccupOralAdult25 - 50 mg three or four times daily.ChildrenNo information available.ElderlyNo information available.IntramuscularAdult25 - 50 mg every 6-8 hours. .ChildrenNo information available.ElderlyNo information availableIntravenous InfusionAdultIf other routes of administration are inappropriate give 25-50 mg in 500-1000 ml sodium chloride by slow intravenous infusion every 6-8 hours.ChildrenNo information available.ElderlyNo information available.Induction of hypothermia to prevent shiveringIntramuscularAdult25 - 50 mg every 6 - 8 hours.ChildrenUnder 1 Year: Do not use in children this age.1-12 Years: Initial dose: 0.5 - 1.0 mg/kg. Maintenance: 0.5 mg/kg every 4 - 6 hours.ElderlyNo information available.Nausea and Vomiting of Terminal IllnessOralAdults10 - 25 mg every 4 - 6 hours.ChildrenUnder 1 Year: Do not use unless need is life saving.1-5 Years; 0.5 mg/kg every 4 - 6 hours. Maximum daily dosage should not exceed 40 mg.6 - 12 Years: 0.5 mg/kg every 4 - 6 hours. Maximum daily dosage should not exceed 75 mg.ElderlyInitially a third to half the adult dose. The physician should then use their clinical judgement to obtain control.IntramuscularAdults25 mg initially then 25 - 50 mg every 3 - 4 hours until vomiting stops then drug to be taken orally.ChildrenUnder 1 Year: Do not use unless need is life saving.1 - 5 Years: 0.5 mg/kg 6 - 8 hourly. It is advised that maximum daily dosage should not exceed 40 mg.6-12 Years: 0.5 mg/kg every 6 - 8 hours. It is advised that maximum daily dosage should not exceed 75 mg.ElderlyFor oral use only.
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About Largactil Thorazine:
Product Type: Prescription Drugs 9
Largactil ( Thorazine Generic Chlorpromazine )
Largactil (Thorazine Generic Chlorpromazine)
Thorazine Generic Chlorpromazine
100mg 100 Tablets 100mg 200(2 x 100) Tablets 10mg 100 Tablets 10mg 200(2 x 100) Tablets 25mg 100 Tablets 25mg 200(2 x 100) Tablets
Thorazine Generic Chlorpromazine Largactil

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From Gulf News: Runners should avoid prescription drugs. Statins may increase production of the enzyme creatine kinase, and hence heighten chances of muscle damage in athletes. Marathon running has increased in popularity over the past three decades, with participation in the United States rising from 25,000 runners in 1976 to nearly 470,000 in 2008. Many professional and recreational runners take prescription drugs, unaware of potential side-effects that affect runners in particular. One such class of drugs, called statins, which includes medicines such as Lipitor, Crestor and Pravachol, lowers blood cholesterol by inhibiting a cholesterol-producing enzyme and may even lower the risks of heart attack and further cardiovascular disease in a narrow category of patients. A new study forthcoming in the American Journal of Cardiology examined the effect of statins on creatine kinase (CK), an enzyme linked to muscle damage. Elevated levels of CK in the blood and muscle after exercise correlates with muscle damage. The study, conducted by Dr Beth Parker of the Henry Low Heart Centre at Connecticut's Hartford Hospital, is the first to measure CK levels in athletes taking statins after physical activity in a real-life environment rather than in a university laboratory.


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