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Isosorbide is used to prevent or treat chest pain (angina). It works by relaxing the blood vessels to the heart so the blood and oxygen supply to the heart is increased.Isosorbide comes as a regular sublingual chewable and extended-release (long-acting) tablet and extended-release (long-acting) capsule to be taken by mouth. The tablet usually is taken every 6 hours. The extended-release tablet usually is taken one or two times a day. The extended-release capsule usually is taken every 8-12 hours. Do not crush chew or divide the extended-release tablets or capsules. The sublingual or chewable tablet is used as needed to relieve chest pain that has already started or to prevent pain before activities known to provoke attacks (e.g. climbing stairs sexual activity heavy exercise or being outside in cold weather). The chewable tablet also may be used every 2-3 hours to prevent chest pain. Follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain any part you do not understand. Take isosorbide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.Isosorbide controls chest pain but does not cure it. Continue to take isosorbide even if you feel well. Do not stop taking isosorbide without talking to your doctor. Stopping the drug abruptly may cause chest pain.Isosorbide can lose its effectiveness when used for a long time. This effect is called tolerance. If your angina attacks happen more often last longer or are more severe call your doctor.If you are using isosorbide sublingual or chewable tablets for acute chest pain you should carry the tablets with you at all times. If you are taking isosorbide and your chest pain is not relieved within 5-10 minutes take another dose. Call for emergency assistance or go to a hospital emergency department if pain persists after you have taken three tablets (at 5-10-minute intervals) and 15-30 minutes have passed.When an attack occurs sit down. If you use chewable tablets chew a tablet thoroughly and swallow it. To use the sublingual tablets place a tablet under your tongue or between your cheek and gum and allow it to dissolve. Do not swallow the tablet. Try not to swallow saliva too often until the tablet dissolves.Isosorbide tablets are also used with other drugs to treat congestive heart failure.
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Duride (Imdur Ismo Isotrate ER Monoket Generic Isosorbide mononitrate)
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From Gulf News: Runners should avoid prescription drugs. Statins may increase production of the enzyme creatine kinase, and hence heighten chances of muscle damage in athletes. Marathon running has increased in popularity over the past three decades, with participation in the United States rising from 25,000 runners in 1976 to nearly 470,000 in 2008. Many professional and recreational runners take prescription drugs, unaware of potential side-effects that affect runners in particular. One such class of drugs, called statins, which includes medicines such as Lipitor, Crestor and Pravachol, lowers blood cholesterol by inhibiting a cholesterol-producing enzyme and may even lower the risks of heart attack and further cardiovascular disease in a narrow category of patients. A new study forthcoming in the American Journal of Cardiology examined the effect of statins on creatine kinase (CK), an enzyme linked to muscle damage. Elevated levels of CK in the blood and muscle after exercise correlates with muscle damage. The study, conducted by Dr Beth Parker of the Henry Low Heart Centre at Connecticut's Hartford Hospital, is the first to measure CK levels in athletes taking statins after physical activity in a real-life environment rather than in a university laboratory.


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